Literatur

Survival and effectiveness of leflunomide compared with methotrexate and sulfasalazine in rheumatoid arthritis: a matched observational study.
Aletaha D, Stamm T, Kapral T, Eberl G, Grisar J, Machold KP, Smolen JS.
Division of Rheumatology, Department of Internal Medicine III, University of Vienna, Austria. daniel.aletaha(at)akh-wien.ac.at
Ann Rheum Dis. 2003 Oct;62(10):944-51.
online abrufbar

Two-year, blinded, randomized, controlled trial of treatment of active rheumatoid arthritis with leflunomide compared with methotrexate. Utilization of Leflunomide in the Treatment of Rheumatoid Arthritis Trial Investigator Group.
Cohen S, Cannon GW, Schiff M, Weaver A, Fox R, Olsen N, Furst D, Sharp J, Moreland L, Caldwell J, Kaine J, Strand V.
St Paul Medical Center, Dallas, TX, USA.
Arthritis Rheum. 2001 Sep;44(9):1984-92
online abrufbar

Efficacy and safety of leflunomide and predisposing factors for treatment response in patients with active rheumatoid arthritis: RELIEF 6-month data.
Dougados M, Emery P, Lemmel EM, de la Serna R, Zerbini CA, Brin S, van Riel P.
Rene Descartes University, Hopital Cochin, 27 rue du Faubourg Saint-Jacques, 75679 Paris Cedex 14, France.
J Rheumatol. 2003 Dec;30(12):2572-9.
online abrufbar

A comparison of the efficacy and safety of leflunomide and methotrexate for the treatment of rheumatoid arthritis.
Emery P, Breedveld FC, Lemmel EM, Kaltwasser JP, Dawes PT, Gomor B, Van Den Bosch F, Nordstrom D, Bjorneboe O, Dahl R, Horslev-Petersen K, Rodriguez De La Serna A, Molloy M, Tikly M, Oed C, Rosenburg R, Loew-Friedrich I.
Department of Rheumatology and Rehabilitation, University of Leeds School of Medicine, Leeds, UK.
Rheumatology (Oxford). 2000 Jun;39(6):655-65.
online abrufbar

Long term evaluation of radiographic disease progression in a subset of patients with rheumatoid arthritis treated with leflunomide beyond 2 years.
van der Heijde D, Kalden J, Scott D, Smolen J, Strand V.
Division of Internal Medicine, Department of Rheumatology, University Hospital Maastricht, 6202 AZ Maastricht, The Netherlands. dhe(at)sint.azm.nl
Ann Rheum Dis. 2004 Jun;63(6):737-9.
online abrufbar

Improved functional ability in patients with rheumatoid arthritis--longterm treatment with leflunomide versus sulfasalazine. European Leflunomide Study Group.
Kalden JR, Scott DL, Smolen JS, Schattenkirchner M, Rozman B, Williams BD, Kvien TK, Jones P, Williams RB, Oed C, Rosenburg R; European Leflunomide Study Group.
Department of Internal Medicine III, University of Erlangen-Nuremberg, Germany. joachim.kalden(at)med3.med.uni-erlangen.de
J Rheumatol. 2001 Sep;28(9):1983-91
online abrufbar

The efficacy and safety of leflunomide in patients with active rheumatoid arthritis: a five-year followup study.
Kalden JR, Schattenkirchner M, Sorensen H, Emery P, Deighton C, Rozman B, Breedveld F.
Department of Internal Medicine III, University of Erlangen-Nuremberg, Erlangen, Germany. joachim.kalden(at)med3.med.uni-erlangen.de
Arthritis Rheum. 2003 Jun;48(6):1513-20.
online abrufbar

Efficacy and safety of leflunomide in the treatment of psoriatic arthritis and psoriasis: a multinational, double-blind, randomized, placebo-controlled clinical trial.
Kaltwasser JP, Nash P, Gladman D, Rosen CF, Behrens F, Jones P, Wollenhaupt J, Falk FG, Mease P; Treatment of Psoriatic Arthritis Study Group.
Abteilung Rheumatologie, Medizinische Klinik III, Zentrum der Innere Medizin, J. W. Goethe-Universitat, Frankfurt am Main, Germany. kaltwasser(at)em.uni-frankfurt.de
Arthritis Rheum. 2004 Jun;50(6):1939-50.
online abrufbar

Combination leflunomide and methotrexate (MTX) therapy for patients with active rheumatoid arthritis failing MTX monotherapy: open-label extension of a randomized, double-blind, placebo controlled trial.
Kremer J, Genovese M, Cannon GW, Caldwell J, Cush J, Furst DE, Luggen M, Keystone E, Bathon J, Kavanaugh A, Ruderman E, Coleman P, Curtis D, Kopp E, Kantor S, Weisman M, Waltuck J, Lindsley HB, Markenson J, Crawford B, Fernando I, Simpson K, Strand V.
Center for Rheumatology, Albany, New York 12206, USA. jkremer(at)joint-docs.com
J Rheumatol. 2004 Aug;31(8):1521-31.
online abrufbar

Concomitant leflunomide therapy in patients with active rheumatoid arthritis despite stable doses of methotrexate. A randomized, double-blind, placebo-controlled trial.
Kremer JM, Genovese MC, Cannon GW, Caldwell JR, Cush JJ, Furst DE, Luggen ME, Keystone E, Weisman MH, Bensen WM, Kaine JL, Ruderman EM, Coleman P, Curtis DL, Kopp EJ, Kantor SM, Waltuck J, Lindsley HB, Markenson JA, Strand V, Crawford B, Fernando I, Simpson K, Bathon JM.
The Center for Rheumatology, LLP, 1367 Washington Avenue, Suite 101, Albany, NY 12206, USA. jkremer(at)joint-docs.com
Ann Intern Med. 2002 Nov 5;137(9):726-33.
online abrufbar

Slowing of disease progression in rheumatoid arthritis patients during long-term treatment with leflunomide or sulfasalazine.
Larsen A, Kvien TK, Schattenkirchner M, Rau R, Scott DL, Smolen JS, Rozman B, Westhovens R, Tikly M, Oed C, Rosenburg R; European Leflunomide Study Group.
Kongsvinger Sjukehus, Norway. arvilar(at)online.no
Scand J Rheumatol. 2001;30(3):135-42.
online abrufbar

Treatment of active rheumatoid arthritis with leflunomide: two year follow up of a double blind, placebo controlled trial versus sulfasalazine.
Scott DL, Smolen JS, Kalden JR, van de Putte LB, Larsen A, Kvien TK, Schattenkirchner M, Nash P, Oed C, Loew-Friedrich I; European Leflunomide Study Group.
King's College Hospital, London, UK. leigh.joyce(at)kcl.ac.uk
Ann Rheum Dis. 2001 Oct;60(10):913-23.
online abrufbar

Treatment with leflunomide slows radiographic progression of rheumatoid arthritis: results from three randomized controlled trials of leflunomide in patients with active rheumatoid arthritis. Leflunomide Rheumatoid Arthritis Investigators Group.
Sharp JT, Strand V, Leung H, Hurley F, Loew-Friedrich I.
Clinical Research/Development, Hoechst Marion Roussel, Inc., Bridgewater, NJ 08807-0800, USA.
Arthritis Rheum. 2000 Mar;43(3):495-505
online abrufbar

Efficacy and safety of the new DMARD leflunomide: comparison to placebo and sulfasalazine in active rheumatoid arthritis.
Smolen JS.
Division of Rheumatology, University of Vienna, Austria.
Scand J Rheumatol Suppl. 1999;112:15-21.
online abrufbar

Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: a double-blind, randomised, multicentre trial. European Leflunomide Study Group.
Smolen JS, Kalden JR, Scott DL, Rozman B, Kvien TK, Larsen A, Loew-Friedrich I, Oed C, Rosenburg R.
Department of Internal Medicine III, University of Vienna, and Centre for Rheumatic Diseases, Lainz Hospital, Austria.
Lancet. 1999 Jan 23;353(9149):259-66.
online abrufbar

Efficacy and safety of leflunomide in active rheumatoid arthritis.
Smolen JS, Emery P.
Division of Rheumatology, University of Vienna, Austria.
Rheumatology (Oxford). 2000 Jun;39 Suppl 1:48-56.
online abrufbar

Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate. Leflunomide Rheumatoid Arthritis Investigators Group.
Strand V, Cohen S, Schiff M, Weaver A, Fleischmann R, Cannon G, Fox R, Moreland L, Olsen N, Furst D, Caldwell J, Kaine J, Sharp J, Hurley F, Loew-Friedrich I.
Stanford University, Calif, USA. vstrand(at)aol.com
Arch Intern Med. 1999 Nov 22;159(21):2542-50.
online abrufbar

Pharmacokinetics, safety, and efficacy of combination treatment with methotrexate and leflunomide in patients with active rheumatoid arthritis.
Weinblatt ME, Kremer JM, Coblyn JS, Maier AL, Helfgott SM, Morrell M, Byrne VM, Kaymakcian MV, Strand V.
Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Arthritis Rheum. 1999 Jul;42(7):1322-8
online abrufbar