TEMPO-Studie

D. van der Heijde, J.J. Gomez-Reino, T. Tuomiranta, J. Kekow, D. Robertson, R. Pedersen, B. Freundlich, D.J. Chang:
EULAR 2007 [THU0213] Combination etanercept and methotrexate halts radiographic damage in patients with moderate RA activity on methotrexate
Ann Rheum Dis 2007; 66 (Suppl II): 191

D. van der Heijde, C. Lukas, S. Fatenejad, R. Landewe D.: 
EULAR 2007 [OP0011] repair of erosions occurs almost exclusevily in damged joints with swelling: post hoc analysis of radiographic data frpm year 1 from the TEMPO study
Ann Rheum Dis 2007; 66 (Suppl II): 54

Landewe R, van der Heijde D, Klareskog L, van Vollenhoven R, Fatenejad S.
Disconnect between inflammation and joint destruction after treatment with etanercept plus methotrexate: results from the trial of etanercept and methotrexate with radiographic and patient outcomes.
Arthritis Rheum. 2006 Oct;54(10):3119-25. 

van der Heijde D, Klareskog L, Rodriguez-Valverde V, Codreanu C, Bolosiu H, Melo-Gomes J, Tornero-Molina J, Wajdula J, Pedersen R, Fatenejad S
Comparison of etanercept and methotrexate, alone and combined, in the treatment of rheumatoid arthritis: two-year clinical and radiographic results from the TEMPO study, a double-blind, randomized trial.
Arthritis Rheum. 2006 Apr;54(4):1063-74. 

van der Heijde D, Klareskog L, Singh A, Tornero J, Melo-Gomes J, Codreanu C, Pedersen R, Freundlich B, Fatenejad S. 
Patient reported outcomes in a trial of combination therapy with etanercept and methotrexate for rheumatoid arthritis: the TEMPO trial
Ann Rheum Dis. 2006 Mar;65(3):328-34. 

L. Klareskog, D. Van der Heijde, J. Wajdula, R. Pedersen, S. Fatenejad
EULAR 2005 [OP0009] SUSTAINED EFFICACY AND SAFETY OF ETANERCEPT AND METHOTREXATE, COMBINED AND ALONE, IN RA PATIENTS: YEAR 3 TEMPO TRIAL RESULTS
Ann Rheum Dis 2005;64(Suppl III):59

van der Heijde D, Klareskog L, Boers M, Landewe R, Codreanu C, Bolosiu HD, Pedersen R, Fatenejad S:
Comparison of different definitions to classify remission and sustained remission: 1 year TEMPO results.
Ann Rheum Dis. 2005 Nov;64(11):1582-7. Epub 2005 Apr 28.

van der Heijde D, Landewe R, Klareskog L, Rodriguez-Valverde V, Settas L, Pedersen R, Fatenejad S.
Presentation and analysis of data on radiographic outcome in clinical trials: experience from the TEMPO study.
Arthritis Rheum. 2005 Jan;52(1):49-60. 

Kobelt G, Lindgren P, Singh A, Klareskog L.
Cost effectiveness of etanercept (Enbrel) in combination with methotrexate in the treatment of active rheumatoid arthritis based on the TEMPO trial.
Ann Rheum Dis. 2005 Aug;64(8):1174-9. Epub 2005 Feb 11.

Klareskog L, van der Heijde D, de Jager JP, Gough A, Kalden J, Malaise M, Martin Mola E, Pavelka K, Sany J, Settas L, Wajdula J, Pedersen R, Fatenejad S, Sanda M:
Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial.
Lancet. 2004 Feb 28;363(9410):675-81.